EPR study of anion radicals of various N-quinonyl amino acids

被引：13

作者：

Bittner, S

Gorohovsky, S

Lozinsky, E

Shames, AI

机构：

[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Dept Phys, IL-84105 Beer Sheva, Israel

来源：

AMINO ACIDS | 2000年 / 19卷 / 02期

关键词：

amino acids; EPR; semiquinone radical; N-quinonyl amino acids; hyperfine splittings;

D O I：

10.1007/s007260070022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since peptide quinones possess great clinical potential in targeted chemotherapy, several series of novel N-quinonyl amino acids have been synthesized and their first products of reduction were studied by EPR spectroscopy. EPR spectra of the corresponding radical adducts were identified by computer simulation. The dependence between the splitting constants and the chemical structure of the N-quinonyl amino acids anion radicals was examined.

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收藏

页码：439 / 449

页数：11

相关论文

共 21 条

[1] DEOXYRIBOSE BREAKDOWN BY THE ADRIAMYCIN SEMI-QUINONE AND H2O2 - EVIDENCE FOR HYDROXYL RADICAL PARTICIPATION [J].

BATES, DA ;

WINTERBOURN, CC .

FEBS LETTERS, 1982, 145 (01) :137-142

[2]

CLAY JDR, 1981, J CHEM SOC FARADAY T, V277, P1589

[3]

Dimroth O, 1940, LIEBIGS ANN CHEM, V545, P124

[4] GONADOTROPIN-RELEASING-HORMONE AGONISTS - A GUIDE TO USE AND SELECTION [J].

FILICORI, M .

DRUGS, 1994, 48 (01) :41-58

[5] GENERATION OF FREE-RADICALS AND LIPID PEROXIDATION BY REDOX CYCLING OF ADRIAMYCIN AND DAUNOMYCIN [J].

GOODMAN, J ;

HOCHSTEIN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 77 (02) :797-803

[6] MECHANISM(S) OF BIOREDUCTIVE ACTIVATION - THE EXAMPLE OF DIAZIQUONE (AZQ) [J].

GUTIERREZ, PL .

FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (04) :405-445

[7] FREE-RADICAL DAMAGE TO DEOXYRIBOSE BY ANTHRACYCLINE, AUREOLIC ACID AND AMINOQUINONE ANTITUMOUR ANTIBIOTICS - AN ESSENTIAL REQUIREMENT FOR IRON, SEMIQUINONES AND HYDROGEN-PEROXIDE [J].

GUTTERIDGE, JMC ;

QUINLAN, GJ .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (23) :4099-4103

[8] OXYGEN-TOXICITY, OXYGEN RADICALS, TRANSITION-METALS AND DISEASE [J].

HALLIWELL, B ;

GUTTERIDGE, JMC .

BIOCHEMICAL JOURNAL, 1984, 219 (01) :1-14

[9]

HEWGILL FR, 1996, MAG RES CHEM, V51, P47

[10] ANALOGS OF LUTEINIZING-HORMONE-RELEASING HORMONE CONTAINING CYTOTOXIC GROUPS [J].

JANAKY, T ;

JUHASZ, A ;

BAJUSZ, S ;

CSERNUS, V ;

SRKALOVIC, G ;

BOKSER, L ;

MILOVANOVIC, S ;

REDDING, TW ;

REKASI, Z ;

NAGY, A ;

SCHALLY, AV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (03) :972-976