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Preparative resolution of 2-methyl-4-hexynic acid for the synthesis of optically active m-phenylene PGI2 derivatives and determination of their absolute configuration

被引：13
作者：
Wakita, H
Yoshiwara, H
Kitano, Y
Nishiyama, H
Nagase, H
机构：
[1] Toray Ind Inc, Basic Res Labs, Kamakura, Kanagawa 2488555, Japan
[2] Toray Res Ctr Ltd, Otsu, Shiga 5208567, Japan
[3] Toyohashi Univ Technol, Sch Mat Sci, Toyohashi, Aichi 4418580, Japan
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 14期
关键词：
D O I：
10.1016/S0957-4166(00)00251-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Racemic 2-methyl-4-hexynic acid, which is a starting material for the omega-side chain of the PGI(2) derivatives, Beraprost and Iloprost, was efficiently resolved on a preparative scale by diastereomeric salt formation using quinine and cinchonidine as resolving agents, Their absolute configuration was determined by X-ray analyses of Beraprost derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2981 / 2989
页数：9
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