Antigen-processing machinery breakdown and tumor growth

被引：377

作者：

Seliger, B

Maeurer, MJ

Ferrone, S

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Internal Med 3, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Dept Med Microbiol, D-55131 Mainz, Germany

[3] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(00)01692-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.

引用

页码：455 / 464

页数：10

共 98 条

[1] Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations
Abrams, SI
Khleif, SN
Bergmann-Leitner, ES
Kantor, JA
Chung, Y
Hamilton, JM
Schlom, J
[J]. CELLULAR IMMUNOLOGY, 1997, 182 (02) : 137 - 151
[2] ALBINO AP, 1992, ONCOGENE, V7, P2315
[3] Alpan RS, 1996, CANCER RES, V56, P4358
[4] K-ras mutations and HLA-DR expression in large bowel adenomas
Andersen, SN
Breivik, J
Lovig, T
Meling, GI
Gaudernack, G
Clausen, OPF
Schjolberg, A
Fausa, O
Langmark, F
Lund, E
Rognum, TO
[J]. BRITISH JOURNAL OF CANCER, 1996, 74 (01) : 99 - 108
[5] Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity
Armstrong, TD
Clements, VK
Martin, BK
Ting, JPY
OstrandRosenberg, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) : 6886 - 6891
[6] Deficient major histocompatibility complex class II antigen presentation in a subset of Hodgkin's diseasetumor cells
Bosshart, H
Jarrett, RF
[J]. BLOOD, 1998, 92 (07) : 2252 - 2259
[7] HLA-G: a tolerance molecule from the major histocompatibility complex
Carosella, ED
Rouas-Freiss, N
Paul, P
Dausset, J
[J]. IMMUNOLOGY TODAY, 1999, 20 (02): : 60 - 62
[8] Binding and transport of melanoma-specific antigenic peptides by the transporter associated with antigen processing
Chang, SA
Lacaille, VG
Guttoh, DS
Androlewicz, MJ
[J]. MOLECULAR IMMUNOLOGY, 1996, 33 (15) : 1165 - 1169
[9] Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4+ T lymphocytes
Chaux, P
Vantomme, V
Stroobant, V
Thielemans, K
Corthals, J
Luiten, R
Eggermont, AMM
Boon, T
van der Bruggen, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) : 767 - 777
[10] A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer
Chen, HL
Gabrilovich, D
Tampe, R
Girgis, KR
Nadaf, S
Carbone, DP
[J]. NATURE GENETICS, 1996, 13 (02) : 210 - 213

← 1 2 3 4 5 6 7 8 9 10 →