Sentinel lymph node and breast cancer staging:: Final results of the Turin multicenter study

被引:7
作者
Casalegno, PS
Sandrucci, S
Bellò, M
Durando, A
Danese, S
Silvestro, L
Pellerito, R
Testori, O
Roagna, R
Giai, M
Giani, R
Bussone, R
Favero, A
Bisi, G
Massobrio, M
Giardina, G
Mussa, GC
Sismondi, P
Mussa, A
机构
[1] Univ Turin, Unita Operat Chirurg Oncol, Turin, Italy
[2] Univ Turin, Nucl Med Serv, Turin, Italy
[3] Univ Turin, Clin 1, Dipartimento Ginecol & Ostetr, Turin, Italy
[4] AO OIRM S Anna, Div Gineol & Ostetr A, Turin, Italy
[5] AO OIRM S Anna, Nucl Med Serv, Turin, Italy
[6] Univ Turin, Dipartimento Ginecol Oncol, Turin, Italy
[7] Osped Mauriziano Umberto 1, Nucl Med Serv, Turin, Italy
[8] Osped S Giovanni Antica Sede, Turin, Italy
来源
TUMORI JOURNAL | 2000年 / 86卷 / 04期
关键词
breast carcinoma; multicenter study; sentinel lymph node; staging;
D O I
10.1177/030089160008600409
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim of the study: Validation of the sentinel node (SN) technique in breast cancer by means of lymphoscintigraphy. Materials and methods: From December 1996 to January 1999 102 T-1-T-2 breast carcinoma cases were recruited in Turin, Tc-99m-human serum albumin colloids were injected subdermally the day before surgery (mean activity, 5.2 +/- 2.5 MBq). Scintigraphic imaging was performed after injection. After identification of the SN during surgery by a hand-held gamma probe, the SN was excised and sent for histologic examination. SN histology was compared with that of other axillary nodes. Results: The SN detection rate was 86.3%; among 88 cases with an identified SN, 37 (42%) had axillary metastases; the SN was metastatic in 35 cases (sensitivity, 94.6%); in 51.3% of pN+ cases (19/37) the SN was the only metastatic site. In two of the 53 negative SNs, SN histology did not match with that of the remaining axilla (negative predictive value, 96.2%; staging accuracy, 97.7%), Conclusions: Our results agree with those reported in the literature; however, except in clinical trials and experienced structures axillary lymph node dissection should not be abandoned when mandatory for prognostic purposes, considering that at present SN biopsy alone is not completely accurate for axillary staging, especially in the absence of an adequate learning period.
引用
收藏
页码:300 / 303
页数:4
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