Direct oxidative heck cyclizations: Intramolecular Fujiwara-Moritani arylations for the synthesis of functionalized benzofurans and dihydrobenzofurans

被引：206

作者：

Zhang, HM ^{[1
]}

Ferreira, EM ^{[1
]}

Stoltz, BM ^{[1
]}

机构：

[1] CALTECH, Arnold & Mabel Beckman Labs Chem Synth, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 45期

关键词：

benzofurans; homogeneous catalysis; oxidation; palladium;

D O I：

10.1002/anie.200461294

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

No extra functionalization step is required for palladium(II)-catalyzed oxidative carbocyclizations like that shown, which provide highly substituted benzofuran and dihydrobenzofuran derivatives by net dehydrogenation. The mechanism is similar to that of Heck cyclizations. Products containing quaternary carbon stereocenters can be obtained in diastereomerically pure form.

引用

页码：6144 / 6148

页数：5

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