Role of the interleukin-6-174 G>C gene polymorphism in retinal artery occlusion

被引：18

作者：

Weger, M

Steinbrugger, I

Haas, A

März, W

El-Shabrawi, Y

Weger, W

Schmut, O

Renner, W

机构：

[1] Med Univ, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

[2] Med Univ, Dept Ophthalmol, A-8036 Graz, Austria

来源：

STROKE | 2005年 / 36卷 / 02期

关键词：

atherosclerosis; genetics; interleukin-6; ophthalmology; retinal artery occlusion; risk factors;

D O I：

10.1161/01.STR.0000151329.84830.37

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis. A common polymorphism in the promoter of the IL-6 gene (IL-6 -174G>C) affects plasma IL-6 concentrations and has been suggested as a risk factor for cardiovascular disease. The aim of the present case-control study was to investigate the role of this polymorphism for retinal artery occlusion (RAO). Methods-One hundred eighty-two patients with RAO and 307 control subjects were genotyped for the IL-6 -174G>C polymorphism. Genotypes were determined by fluorogenic exonuclease (TaqMan) assay. Results-The prevalence of the CC genotype was significantly lower in patients with RAO than in control subjects (10.4% versus 19.9%; P = 0.006). Homozygosity for the C allele was associated with an odds ratio of 0.50 (95% CI, 0.28 to 0.89) for RAO. Conclusions-The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against RAO.

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页码：249 / 252

页数：4

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