Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

被引：31

作者：

Lam, PYS ^{[1
]}

Adams, JJ ^{[1
]}

Clark, CG ^{[1
]}

Calhoun, WJ ^{[1
]}

Luettgen, JM ^{[1
]}

Knabb, RM ^{[1
]}

Wexler, RR ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00130-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an effort to identify orally bioavailable factor Xa inhibitors, two isoxazolines libraries were prepared to scan for novel P1 ligands. From this work, 4-chloro-3-aniline was identified as a novel and potent benzamidine mimic. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1795 / 1799

页数：5

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