Overlap of promoter and coding sequences in the mouse STOP gene (Mtap6)

被引：14

作者：

Aguezzoul, M

Andrieux, A ^{[1
]}

Denarier, E

机构：

[1] CEA Grenoble, Lab Cytosquelette, Dept Reponse, INSERM, F-38054 Grenoble 9, France

[2] INSERM, Lab Cytosquelette, Dynam Cell, F-38054 Grenoble, France

来源：

GENOMICS | 2003年 / 81卷 / 06期

关键词：

D O I：

10.1016/S0888-7543(03)00053-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The microtubule-associated proteins STOP are essential for synaptic plasticity and integrated brain function. The STOP gene (Mtap6) is composed of 4 exons and presents different developmental and tissue specific alternative transcripts resulting in the neuronal isoforms E- and N-STOP, and in the fibroblastic F-STOP isoform. We now characterize the transcription initiation sites for neuronal and non neuronal STOP transcripts. Our results show that there is a single neuronal specific promoter for transcription of E- and N-STOP mRNAs. F-STOP mRNA transcription is regulated by a distinct promoter. A remarkable feature of this promoter is that it lies within coding sequences expressed in neuronal E- and N-STOP isoforms. (C) 2003 Elsevier Science (USA). All rights reserved.

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收藏

页码：623 / 627

页数：5

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