Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population

被引：27

作者：

Taylor, MC

Le Couteur, DG

Mellick, GD

Board, PG

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Mol Genet Grp, Acton, ACT 2601, Australia

[2] Univ Sydney, Canberra Hosp, Canberra Clin Sch, Canberra, ACT, Australia

[3] Univ Queensland, Dept Med, Brisbane, Qld, Australia

来源：

JOURNAL OF NEURAL TRANSMISSION | 2000年 / 107卷 / 8-9期

关键词：

Parkinson's disease; paraoxonase; polymorphism;

D O I：

10.1007/s007020070046

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.

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页码：979 / 983

页数：5

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