Apoptosis - Death cycle and Swiss army knives

被引：97

作者：

Hengartner, MO ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE | 1998年 / 391卷 / 6666期

关键词：

D O I：

10.1038/35036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a cell starts to undergo programmed cell death, cytochromec moves from the mitochondria, where it usually acts in an electron-transfer chain, to the cytosol. One of the relatively recent dogmas of apoptosis is that the death-suppressing protein Bcl-2 acts before cytochrome c in this pathway. But two new papers could overturn this dogma, by showing that Bcl-2 can also protect cells after cytochrome chas been released.

引用

页码：441 / 442

页数：2

共 13 条

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[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) : 608 - 615
[3] A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
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[J]. NATURE, 1998, 391 (6662) : 43 - 50
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[J]. SCIENCE, 1997, 275 (5303) : 1132 - 1136
[7] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
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[J]. NATURE, 1997, 387 (6635) : 773 - 776
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Rager, M
Conus, S
Fellay, I
Jansen, B
Borner, C
[J]. NATURE, 1998, 391 (6666) : 496 - 499

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