A new role for Ran in ensuring precise duplication of chromosomal DNA

被引：6

作者：

Blow, JJ ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland

来源：

CELL | 2003年 / 113卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(03)00236-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To prevent re-replication of DNA, the licensing of replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue of Cell) shows that the small GTPase Ran can directly inhibit licensing inside nuclei once CDKs are active late in the cell cycle.

引用

页码：2 / 4

页数：3

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