Stem cell therapies for ocular surface disease

被引：50

作者：

Ahmad, Sajjad ^{[2
]}

Kolli, Sai ^{[3
]}

Lako, Majlinda ^{[2
]}

Figueiredo, Francisco ^{[2
]}

Daniels, Julie T. ^{[1
]}

机构：

[1] UCL, Inst Ophthalmol, Cells Sight Transplantat & Res Programme, London EC1V 9EL, England

[2] NE England Stem Cell Inst, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[3] Moorfields Eye Hosp NHS Fdn Trust, London EC1V 2PD, England

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 7-8期

基金：

英国医学研究理事会;

关键词：

BASEMENT-MEMBRANE HETEROGENEITY; KERATINOCYTE GROWTH-FACTOR; HUMAN LIMBAL EPITHELIUM; EX-VIVO; IN-VITRO; TRANSPLANTATION; CULTURE; RECONSTRUCTION; EXPRESSION; DIFFERENTIATION;

D O I：

10.1016/j.drudis.2010.02.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.

引用

页码：306 / 313

页数：8

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