DNA polymorphism in B-domain of the estrogen receptor-μ among Japanese women

A silent mutation in B-domain of the estrogen receptor-alpha (ER B) change codon 87 (from GCG to GCC) is clinically con-elated with frequent spontaneous abortion and familial history of breast cancer among Caucasian patients. However, none of the 167 Japanese female patients and 46 Japanese female healthy volunteers showed ER B variant. Therefore, this DNA polymorphism might involve a genetic racial difference, and appears not to be correlated with frequent spontaneous abortion of familial history of breast cancer at least among Japanese women. (C) 1998 by Elsevier Science Inc.