Hypervirulence and pathogen fitness

被引：50

作者：

Foreman-Wykert, AK ^{[1
]}

Miller, JF ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0966-842X(03)00007-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Historically, pathogenesis research has focused on the identification and characterization of virulence factors. More recently, 'anti-virulence' genes have been discovered. Mutations in these loci result in a hypervirulent phenotype, as measured by a lower lethal dose, a colonization advantage, reduced clearance or decreased survival time of the host. If these genes function to reduce pathogen virulence, why have they been retained? Multiple hypotheses have been offered to explain this phenomenon.

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页码：105 / 108

页数：4

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