The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells

被引：39

作者：

Arao, K

Yotsumoto, H

Han, SY

Nagao, K

Yanagita, T

机构：

[1] Saga Univ, Dept Appl Biol Sci, Saga 8408502, Japan

[2] Saga Jr Coll, Dept Food Sci & Nutr, Saga 8400806, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 12期

关键词：

conjugated linolenic acid; apolipoprotein B100; triacylglycerol synthesis; HepG2;

D O I：

10.1271/bbb.68.2643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein 13100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of C-14-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.

引用

页码：2643 / 2645

页数：3

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