Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1

被引：69

作者：

Hourcade, D ^{[1
]}

Liszewski, MK ^{[1
]}

Krych-Goldberg, M ^{[1
]}

Atkinson, JP ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St Louis, MO 63110 USA

来源：

IMMUNOPHARMACOLOGY | 2000年 / 49卷 / 1-2期

关键词：

complement regulatory proteins; CR1; (CD35); MCP (CD46) and DAF (CD55); pathogen interactions with CR1; MCP; DAF; functional domains of CR1; structural variations in mammals of CR1; regulators of complement (RCA) genes/proteins;

D O I：

10.1016/S0162-3109(00)80296-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Regulators of Complement Activation (RCA) are a fascinating group of proteins that play important roles in innate and acquired immunity. In this review, we examine structure-function aspects of three membrane-bound RCA proteins and discuss the unique impact of their genetic organization on their evolution. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：103 / 116

页数：14

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