A remote substituent as a control element in indium-mediated allylation reactions in aqueous media: highly diastereoselective synthesis of 1,3-amino alcohols

被引：27

作者：

Loh, TP ^{[1
]}

Huang, JM ^{[1
]}

Xu, KC ^{[1
]}

Goh, SH ^{[1
]}

Vittal, JJ ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

allylation; 1,3-amino alcohols; high diastereoselectivity; indium; remote substituent;

D O I：

10.1016/S0040-4039(00)01040-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the stereoselective synthesis of 1,3-amino alcohols based on the indium-mediated allylation of keto ester (R,S)-2 in aqueous media, resulting from shielding of one face by a remote substituent, was developed to be a useful method for acyclic stereocontrol in the absence of any obvious steric interaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6511 / 6515

页数：5

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