Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

被引：83

作者：

Bjarnsholt, Thomas ^{[1
,2
]}

Tolker-Nielsen, Tim ^{[1
]}

Hoiby, Niels ^{[1
,2
]}

Givskov, Michael ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Int Hlth Immunol & Microbiol, DK-2200 Copenhagen, Denmark

[2] Rigshosp, Univ Hosp, Dept Clin Microbiol, DK-2100 Copenhagen, Denmark

来源：

EXPERT REVIEWS IN MOLECULAR MEDICINE | 2010年 / 12卷

关键词：

QUORUM-SENSING INHIBITORS; CYSTIC-FIBROSIS PATIENTS; ACYLATED HOMOSERINE LACTONES; VIRULENCE GENE-EXPRESSION; GRAM-NEGATIVE BACTERIA; TO-CELL SIGNALS; POLYMORPHONUCLEAR LEUKOCYTES; HYDROGEN-PEROXIDE; LUNG INFECTION; CHEMICAL COMMUNICATION;

D O I：

10.1017/S1462399410001420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

引用

页数：19

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