DNA cleavage by 7-methylbenzopentathiepin: A simple analog of the antitumor antibiotic varacin

被引：59

作者：

Chatterji, T

Gates, KS ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00066-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The compound 7-methylbenzopentathiepin, a simple analog of the benzopentathiepin antitumor antibiotic varacin, was shown to be a potent thiol-dependent DNA-cleaving agent. Biological experiments previously suggested that DNA cleavage might play a role in the cytotoxicity of varacin; however, this is the first direct evidence that benzopentathiepins can cause DNA strand breaks under physiologically relevant conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：535 / 538

页数：4

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