Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell

被引：94

作者：

Ohashi, Rina

Takahashi, Fumiyuki

Cui, Ri

Yoshioka, Masakata

Gu, Tao

Sasaki, Shinichi

Tominaga, Shigeru

Nishio, Kazuto

Tanabe, Kenneth K.

Takahashi, Kazuhisa

机构：

[1] Juntendo Univ, Sch Med, Dept Resp Med, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Res Inst Dis Old Ages, Tokyo 1138421, Japan

[3] Natl Inst Canc Res, Div Pharmacol, Chuo Ku, Tokyo 1040045, Japan

[4] Massachusetts Gen Hosp, Dept Surg, Div Surg Oncol, Boston, MA 02114 USA

来源：

CANCER LETTERS | 2007年 / 252卷 / 02期

关键词：

hyaluronate; non-small cell lung cancer; chemoresistance; CD44s; MRP2;

D O I：

10.1016/j.canlet.2006.12.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/ CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：225 / 234

页数：10

共 32 条

[1]

CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].