Transcriptional regulation during B cell development

被引：113

作者：

Henderson, A ^{[1
]}

Calame, K

机构：

[1] Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

[2] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 1998年 / 16卷

关键词：

transcription factor; B cell development; coactivator; primary B lymphopoiesis; antigen-dependent B lymphopoiesis;

D O I：

10.1146/annurev.immunol.16.1.163

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.

引用

页码：163 / 200

页数：38

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