Genetic characterization of methicillin-resistant Staphylococcus aureus

被引:10
作者
Hiramatsu, K [1 ]
Watanabe, S [1 ]
Takeuchi, F [1 ]
Ito, T [1 ]
Baba, T [1 ]
机构
[1] Juntendo Univ, Dept Bacteriol, Bunkyo Ku, Tokyo 1138421, Japan
关键词
Staphylococcus aureus; MRSA; genome;
D O I
10.1016/j.vaccine.2004.08.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The genome structure of Staphylococcus aureus is analyzed. The genome is composed of two domains. The first domain, descendent from an ancestral bacterial species, contains house-keeping genes that showed highest homology to those of Bacillus species. The second domain contained the genes responsible for virulence and drug-resistance in human infection that seems to have been acquired from other bacterial species via lateral gene transfer. The latter domain constitutes the genetic information that makes S. aureus a notorious hospital pathogen. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:S5 / S8
页数:4
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