Synthesis of 4-substituted 1,5-dihydropyrrol-2-ones and 5,6-dihydro-1H-pyridin-2-ones by Negishi cross-coupling reactions:: Short access to the antidepressant (±)-rolipram

被引：18

作者：

Albrecht, Dominik ^{[1
]}

Bach, Thorsten ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany

来源：

SYNLETT | 2007年 / 10期

关键词：

catalysis; cross-coupling; heterocycles; lactams; palladium; zinc;

D O I：

10.1055/s-2007-982553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward access to the title compounds was established by Pd-catalyzed Negishi cross-coupling reactions of the readily available bromides 3 and 6 with various functionalized zinc reagents (71-97% yield).

引用

页码：1557 / 1560

页数：4

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