Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

被引：660

作者：

Altare, F

Durandy, A

Lammas, D

Emile, JF

Lamhamedi, S

Le Deist, F

Drysdale, P

Jouanguy, E

Döffinger, R

Bernaudin, F

Jeppsson, O

Gollob, JA

Meinl, E

Segal, AW

Fischer, A

Kumararatne, D

Casanova, JL ^{[2
]}

机构：

[1] Hop Necker Enfants Malad, Unite Immunol & Hematol Pediat, F-75015 Paris, France

[2] Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France

[3] UCL, Dept Med, London WC1 E6JJ, England

[4] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

[6] Univ Hosp, Dept Pediat, S-14501 Norsborg, Sweden

[7] Ctr Hosp Intercommunal, Serv Pediat, F-94010 Creteil, France

[8] Hop Paul Brousse, Serv Anatomopathol, F-94804 Villejuif, France

[9] Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England

来源：

SCIENCE | 1998年 / 280卷 / 5368期

关键词：

D O I：

10.1126/science.280.5368.1432

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.

引用

页码：1432 / 1435

页数：4

共 40 条

[1] A causative relationship between mutant IFNgR1 alleles and impaired cellular response to IFNγ in a compound heterozygous child [J].

Altare, F ;

Jouanguy, E ;

Lamhamedi-Cherradi, S ;

Fondanèche, MC ;

Fizame, C ;

Ribiérre, F ;

Merlin, G ;

Dembic, Z ;

Schreiber, R ;

Lisowska-Grospierre, B ;

Fischer, A ;

Seboun, E ;

Casanova, JL .

AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (03) :723-726

[2]

ALTARE F, 1997, RES INFECT DIS B I P, V95, P143

[3]

ANDERSON P, 1990, J IMMUNOL, V144, P574

[4] The IFN gamma receptor: A paradigm for cytokine receptor signaling [J].

Bach, EA ;

Aguet, M ;

Schreiber, RD .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :563-&

[5] A SUGGESTED NOMENCLATURE FOR DESIGNATING MUTATIONS [J].

BEAUDET, AL ;

TSUI, LC .

HUMAN MUTATION, 1993, 2 (04) :245-248

[6]

Billiau A, 1996, ADV IMMUNOL, V62, P61, DOI 10.1016/S0065-2776(08)60428-9

[7] Cellular responses to interferon-gamma [J].

Boehm, U ;

Klamp, T ;

Groot, M ;

Howard, JC .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795

[8] IMMUNOLOGICAL CONDITIONS OF CHILDREN WITH BCG DISSEMINATED INFECTION [J].

CASANOVA, JL ;

JOUANGUY, E ;

LAMHAMEDI, S ;

BLANCHE, S ;

FISCHER, A .

LANCET, 1995, 346 (8974) :581-581

[9]

Casanova JL, 1996, PEDIATRICS, V98, P774

[10]

CASANOVA JL, IN PRESS PRIMARY IMM

← 1 2 3 4 →