Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D

被引：139

作者：

Garland, Cedric F. ^{[1
]}

Kim, June Jiwon ^{[2
]}

Mohr, Sharif Burgette ^{[2
]}

Gorham, Edward Doerr ^{[1
]}

Grant, William B. ^{[3
]}

Giovannucci, Edward L. ^{[4
,5
]}

Baggerly, Leo ^{[6
]}

Hofflich, Heather ^{[7
]}

Ramsdell, Joe Wesley ^{[7
]}

Zeng, Kenneth ^{[2
]}

Heaney, Robert P. ^{[8
]}

机构：

[1] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA

[2] Leidos Biomed Res Inc, San Diego, CA USA

[3] Sunlight & Nutr Res Ctr, San Francisco, CA USA

[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[6] GrassrootsHealth, Res Dept, San Diego, CA USA

[7] Univ Calif San Diego, Dept Med, Internal Med Grp, La Jolla, CA 92093 USA

[8] Creighton Univ, Dept Med, Omaha, NE 68178 USA

来源：

AMERICAN JOURNAL OF PUBLIC HEALTH | 2014年 / 104卷 / 08期

关键词：

CARDIOVASCULAR-DISEASE MORTALITY; VITAMIN-D CONCENTRATIONS; BREAST-CANCER; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; COLORECTAL-CANCER; FOREST PLOTS; COLON-CANCER; OLDER MEN; RISK;

D O I：

10.2105/AJPH.2014.302034

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We examined the relationship between serum 25-hydroxyvitamin D (25[OH] D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH) D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for all-cause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH) D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001). Serum 25 (OH) D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.

引用

页码：E43 / E50

页数：8

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