Point Mutations Are Causing Progeroid Phenotypes in the mtDNA Mutator Mouse

被引：7

作者：

Edgar, Daniel ^{[1
]}

Larsson, Nils-Goran ^{[1
,2
]}

Trifunovic, Aleksandra ^{[1
,3
]}

机构：

[1] Karolinska Inst, Dept Lab Med, Div Metab Dis, S-14186 Huddinge, Sweden

[2] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[3] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

来源：

CELL METABOLISM | 2010年 / 11卷 / 01期

关键词：

MICE; DELETIONS;

D O I：

10.1016/j.cmet.2009.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1 / 1

页数：1

共 4 条

[1] Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice [J].

Edgar, Daniel ;

Shabalina, Irina ;

Camara, Yolanda ;

Wredenberg, Anna ;

Calvaruso, Maria Antonietta ;

Nijtmans, Leo ;

Nedergaard, Jan ;

Cannon, Barbara ;

Larsson, Nils-Goeran ;

Trifunovic, Aleksandra .

CELL METABOLISM, 2009, 10 (02) :131-138

[2] Quantification of mitochondrial DNA mutation load [J].

Greaves, Laura C. ;

Beadle, Nina E. ;

Taylor, Geoffrey A. ;

Commane, Daniel ;

Mathers, John C. ;

Khrapko, Konstantin ;

Turnbull, Doug M. .

AGING CELL, 2009, 8 (05) :566-572

[3] Do mtDNA deletions drive premature aging in mtDNA mutator mice? [J].

Kraytsberg, Yevgenya ;

Simon, David K. ;

Turnbull, Douglas M. ;

Khrapko, Konstantin .

AGING CELL, 2009, 8 (04) :502-506

[4] Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice [J].

Tyynismaa, H ;

Mjosund, KP ;

Wanrooij, S ;

Lappalainen, I ;

Ylikallio, E ;

Jalanko, A ;

Spelbrink, JN ;

Paetau, A ;

Suomalainen, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (49) :17687-17692

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