Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

被引：20

作者：

Ashrani, AA

Reding, MT

Shet, A

Osip, J

Humar, A

Lake, JR

Key, NS

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

[2] Fairview Univ Med Ctr, Hemophilia & Thrombosis Ctr, Minneapolis, MN USA

[3] Univ Minnesota, Sch Med, Dept Surg, Minneapolis, MN 55455 USA

来源：

HAEMOPHILIA | 2004年 / 10卷 / 06期

关键词：

D O I：

10.1111/j.1365-2516.2004.01030.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.

引用

页码：735 / 737

页数：3

共 7 条

[1]

LEWIS JH, 1985, NEW ENGL J MED, V312, P1189

[2] Inhibitor development in prospective clinical trials with recombinant factor VIII preparations in previously untreated patients [J].