White matter hyperintensities and within-person variability in community-dwelling adults aged 60-64 years

被引：96

作者：

Bunce, David ^{[1
]}

Anstey, Kaarin J.

Christensen, Helen

Dear, Keith

Wen, Wei

Sachdev, Perminder

机构：

[1] Brunel Univ, Ctr Cognit & Neuroimaging, Uxbridge UB8 3PH, Middx, England

[2] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT, Australia

[3] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia

[4] Univ New S Wales, Sch Psychiat, Prince Wales Hosp, Inst Neuropsychiat, Sydney, NSW, Australia

来源：

NEUROPSYCHOLOGIA | 2007年 / 45卷 / 09期

基金：

英国医学研究理事会;

关键词：

white matter hyperintensities; MRI; cognitive function; within-person variability; intra-individual variability;

D O I：

10.1016/j.neuropsychologia.2007.02.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60-64 years. Frontal lobe WMH but not WMH from other brain regions (temporal, parietal, and occipital lobes, anterior and posterior horn, periventricular body) were associated with elevated within-person reaction time (RT) variability (trial to trial fluctuations in RT performance) but not performance on several other cognitive tasks including psychomotor speed, memory, and global cognition. The findings are consistent with the view that elevated within-person variability is related to neurobiological disturbance, and that attentional mechanisms supported by the frontal cortex play a key role in this type of variability. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2009 / 2015

页数：7

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