A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma

被引：33

作者：

Okimoto, K

Kouchi, M

Kikawa, E

Toyosawa, K

Koujitani, T

Tanaka, K

Matsuoka, N

Sakurai, J

Hino, O

机构：

[1] Dainippon Pharmaceut Co Ltd, Dev Res Labs, Dept Toxicol & Teratol, Osaka 5640053, Japan

[2] Inst Canc Res, Dept Expt Pathol, Toshima Ku, Tokyo 1708455, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 2000年 / 91卷 / 11期

关键词：

Nihon rats; Tsc2 gene mutant (Eker) rats; renal carcinogenesis; hereditary cancer;

D O I：

10.1111/j.1349-7006.2000.tb00890.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the "Nihon" rat, In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c-Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.

引用

页码：1096 / 1099

页数：4

共 12 条

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[2] A DOMINANT GENE FOR RENAL ADENOMAS IN RAT [J].