Relative and absolute configuration of aloperine

被引：15

作者：

Brosius, AD ^{[1
]}

Ziller, JW ^{[1
]}

Zhang, QM ^{[1
]}

机构：

[1] NATL INST CONTROL PHARMACEUT & BIOL PROD,TEMPLE HEAVEN,BEIJING 100050,PEOPLES R CHINA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1997年 / 53卷

关键词：

D O I：

10.1107/S0108270197009244

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The relative and absolute configuration of the title compound, (6R,7R,9R,11S)-16,17-didehydro-9-de-2-piperidinylormosanine, C15H24N2, has been elucidated. Two X-ray structures, one of the free base of the alkaloid and the second of its dihydrochloride monohydrate salt, C15H26N22+.2Cl(-).H2O, have been determined to unequivocally establish the stereochemistry of aloperine, the parent member of a rare family of lupinine alkaloids.

引用

页码：1510 / 1512

页数：3

共 12 条

[1]

BOCHARNIKOVA AV, 1964, ZH OBSHCH KHIM+, V34, P1025

[2]

BROACH RW, 1978, CARESS

[3]

CHENG PT, 1976, TETRAHEDRON LETT, V17, P4245

[4] ON ENANTIOMORPH-POLARITY ESTIMATION [J].

FLACK, HD .

ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (NOV) :876-881

[5] ABSOLUTE MOLECULAR-STRUCTURE OF (-)-PODOPETALINE [J].

MACKAY, MF ;

MATHIESON, AM ;

SATZKE, L .

TETRAHEDRON, 1975, 31 (10) :1295-1298

[6] CRYSTAL AND MOLECULAR-STRUCTURE OF AN OPTICALLY-ACTIVE 16-EPIORMOSANINE [J].

MACKAY, MF ;

MCCALL, MJ ;

POPPLETON, BJ .

JOURNAL OF CRYSTAL AND MOLECULAR STRUCTURE, 1976, 6 (03) :125-137

[7]

MACKAY MF, 1980, CRYST STRUCT COMMUN, V9, P805

[8] THE ALKALOIDS OF PODOPETALUM-ORMONDII [J].

MCLEAN, S ;

MISRA, R ;

KUMAR, V ;

LAMBERTON, JA .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1981, 59 (01) :34-37

[9]

ORECHOFF A, 1935, CHEM BER, V68, P431

[10]

SHELDRICK GM, 1994, SHELXTL STRUCTURE DE

← 1 2 →