The neuroscience of tinnitus

被引:891
作者
Eggermont, JJ [1 ]
Roberts, LE
机构
[1] Univ Calgary, Dept Physiol & Biophys, Calgary, AB T2N 1N4, Canada
[2] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada
[3] McMaster Univ, Dept Psychol, Hamilton, ON L8S 4K1, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/j.tins.2004.08.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tinnitus is an auditory phantom sensation (ringing of the ears) experienced when no external sound is present. Most but not all cases are associated with hearing loss induced by noise exposure or aging. Neuroscience research has begun to reveal how tinnitus is generated by the brain when hearing loss occurs, and to suggest new avenues for management and prevention of tinnitus following hearing injuries. Downregulation of intracortical inhibition induced by damage to the cochlea or to auditory projection pathways highlights neural processes that underlie the sensation of phantom sound.
引用
收藏
页码:676 / 682
页数:7
相关论文
共 69 条
[1]   Detection of glutamate decarboxylase isoforms in rat inferior colliculus following acoustic exposure [J].
Abbott, SD ;
Hughes, LF ;
Bauer, CA ;
Salvi, R ;
Caspary, DM .
NEUROSCIENCE, 1999, 93 (04) :1375-1381
[2]  
[Anonymous], 1970, CIBA FDN S SENS HEAR, DOI DOI 10.1002/9780470719756.CH15
[3]   Effects of chronic salicylate on GABAergic activity in rat inferior colliculus [J].
Bauer, CA ;
Brozoski, TJ ;
Holder, TM ;
Caspary, DM .
HEARING RESEARCH, 2000, 147 (1-2) :175-182
[4]  
BOSNYAK DJ, IN PRESS CEREB CORTE
[5]   Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus [J].
Brozoski, TJ ;
Bauer, CA ;
Caspary, DM .
JOURNAL OF NEUROSCIENCE, 2002, 22 (06) :2383-2390
[6]   Net interaction between different forms of short-term synaptic plasticity and slow-IPSPs in the hippocampus and auditory cortex [J].
Buonomano, DV ;
Merzenich, MM .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (04) :1765-1774
[7]   Expanding the biological basis of tinnitus: crossmodal origins and the role of neuroplasticity [J].
Cacace, AT .
HEARING RESEARCH, 2003, 175 (1-2) :112-132
[8]   Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization [J].
Candia, V ;
Wienbruch, C ;
Elbert, T ;
Rockstroh, B ;
Ray, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7942-7946
[9]   Age-related changes in GABAA receptor subunit composition and function in rat auditory system [J].
Caspary, DM ;
Holder, TM ;
Hughes, LF ;
Milbrandt, JC ;
McKernan, RM ;
Naritoku, DK .
NEUROSCIENCE, 1999, 93 (01) :307-312
[10]   Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices [J].
Chang, H ;
Chen, K ;
Kaltenbach, JA ;
Zhang, JS ;
Godfrey, DA .
HEARING RESEARCH, 2002, 164 (1-2) :59-68