Clinical-pathologic correlation in a patient with selective loss of hair cells in the vestibular endorgans

被引:14
作者
Baloh, RW [1 ]
Lopez, I [1 ]
Beykirch, K [1 ]
Ishiyama, A [1 ]
Honrubia, V [1 ]
机构
[1] UNIV CALIF LOS ANGELES,DIV HEAD & NECK SURG,SCH MED,LOS ANGELES,CA 90095
关键词
D O I
10.1212/WNL.49.5.1377
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We found a selective loss of vestibular hair cells in a patient followed for more than 10 years with imbalance and oscillopsia due to idiopathic progressive loss of vestibular function. Hearing function and cochlear hair cells were normal. The vestibule-ocular reflex (VOR) gain at high frequencies was relatively maintained despite marked shortening of the dominant VOR time constant (to less than 500 ms). Ultrastructural examination of remaining hair cells showed mitochondrial abnormalities. The ultrashort VOR time constant probably resulted from changes in firing patterns of the primary afferent nerves due to loss of hair cells and impaired energy metabolism in remaining hair cells.
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页码:1377 / 1382
页数:6
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