Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair

被引：431

作者：

Shi, Yufang ^{[1
]}

Hu, Gangzheng ^{[1
]}

Su, Juanjuan ^{[1
]}

Li, Wenzhao ^{[1
]}

Chen, Qing ^{[1
]}

Shou, Peishun ^{[1
]}

Xu, Chunliang ^{[1
]}

Chen, Xiaodong ^{[1
]}

Huang, Yin ^{[1
]}

Zhu, Zhexin ^{[1
]}

Huang, Xin ^{[1
]}

Han, Xiaoyan ^{[1
]}

Xie, Ningxia ^{[1
]}

Ren, Guangwen ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci,Inst Hlth Sci, Key Lab Stem Cell Biol,Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet Microbiol & Immunol, Piscataway, NJ 08854 USA

来源：

CELL RESEARCH | 2010年 / 20卷 / 05期

关键词：

MSCs; immunosuppression; tissue repair; immune diseases; MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; IN-UTERO TRANSPLANTATION; LYMPHOCYTE-PROLIFERATION; PROGENITOR CELLS; CEREBRAL-ISCHEMIA; WOUND REPAIR; RAT MODEL; DIFFERENTIATION; ENGRAFTMENT;

D O I：

10.1038/cr.2010.44

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem cells (MSCs) have great potential for treating various diseases, especially those related to tissue damage involving immune reactions. Various studies have demonstrated that MSCs are strongly immunosuppressive in vitro and in vivo. Our recent studies have shown that un-stimulated MSCs are indeed incapable of immunosuppression; they become potently immunosuppressive upon stimulation with the supernatant of activated lymphocytes, or with combinations of IFN-gamma with TNF-alpha, IL-1 alpha or IL-1 beta. This observation revealed that under certain circumstances, inflammatory cytokines can actually become immunosuppressive. We showed that there is a species variation in the mechanisms of MSC-mediated immunosuppression: immunosuppression by cytokine-primed mouse MSCs is mediated by nitric oxide (NO), whereas immunosuppression by cytokine-primed human MSCs is executed through indoleamine 2, 3-dioxygenase (IDO). Additionally, upon stimulation with the inflammatory cytokines, both mouse and human MSCs secrete several leukocyte chemokines that apparently serve to attract immune cells into the proximity with MSCs, where NO or IDO is predicted to be most active. Therefore, immunosuppression by inflammatory cytokine-stimulated MSCs occurs via the concerted action of chemokines and immune-inhibitory NO or IDO produced by MSCs. Thus, our results provide novel information about the mechanisms of MSC-mediated immunosuppression and for better application of MSCs in treating tissue injuries induced by immune responses.

引用

页码：510 / 518

页数：9

共 81 条

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