The role of salivary lipocalins in blood feeding by Rhodnius prolixus

被引：85

作者：

Andersen, JF ^{[1
]}

Gudderra, NP ^{[1
]}

Francischetti, IMB ^{[1
]}

Ribeiro, JMC ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA

来源：

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | 2005年 / 58卷 / 02期

关键词：

D O I：

10.1002/arch.20032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to overcome host mechanisms that prevent blood loss, the blood-sucking bug Rhodnius prolixus has evolved a complex salivary secretion containing dozens of different proteins. A number of these have been characterized and found to have roles in inhibiting various hemostatic or inflammatory systems. Interestingly, many of these biologically active salivary proteins belong to the lipocalin protein family. A proliferation of lipocalin genes has occurred via gene duplication and subsequent divergence. Functional genomic, proteomic, and functional studies have been performed to probe the role of salivary lipocalins in blood feeding. In the course of these investigations, anticoagulant, antiplatelet, antiinflammatory, and vasodilatory molecules have been described. Published 2005 Wiley-Liss, Inc.(t).

引用

页码：97 / 105

页数：9

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