Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

被引：74

作者：

Ellis, S. R. ^{[1
]}

Soltwisch, J. ^{[2
,3
]}

Paine, M. R. L. ^{[1
]}

Dreisewerd, K. ^{[2
,3
]}

Heeren, R. M. A. ^{[1
]}

机构：

[1] Univ Maastricht, M4I, Maastricht Multimodal Mol Imaging Inst, NL-6229 ER Maastricht, Netherlands

[2] Univ Munster, Inst Hyg, Robert Koch Str 41, D-48149 Munster, Germany

[3] Univ Munster, Interdisciplinary Ctr Clin Res IZKF, Domagkstr 3, D-48149 Munster, Germany

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 53期

关键词：

PROTEINS;

D O I：

10.1039/c7cc02325a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to B100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

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收藏

页码：7246 / 7249

页数：4

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