USEFULNESS OF IFN-GAMMA RELEASE ASSAYS IN CLINICAL MANAGEMENT OF DIFFICULT TB CASES: EVIDENCE FROM CLINICAL PRACTICE

被引：10

作者：

Bocchino, M. ^{[1
]}

Matarese, A. ^{[1
]}

Bellofiore, B. ^{[1
]}

Giacomelli, P. ^{[1
]}

Russo, A. ^{[2
]}

Signoriello, G. ^{[3
]}

Galati, D. ^{[4
]}

Sanduzzi, A. ^{[1
]}

机构：

[1] Univ Naples Federico 2, Sch Biotechnol Sci, Dept Clin & Expt Med, TB Infect Screening Unit,Resp Med Sect, I-80131 Naples, Italy

[2] Monaldi Hosp, Thisiol Div, Naples, Italy

[3] Univ Naples 2, Dept Med & Publ Hlth, Naples, Italy

[4] Natl Canc Inst G Pascale, Immunol Sect, Naples, Italy

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2010年 / 8卷 / 01期

关键词：

IFN-gamma release assays; smear-negative tuberculosis; extra-pulmonary tuberculosis; ENZYME-LINKED IMMUNOSPOT; INTERFERON-GAMMA; TUBERCULOSIS; DIAGNOSIS;

D O I：

10.1177/1721727X1000800107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Performance of T-SPOT.TB (TM) (TS-TB) and QuantiFERON TB Gold-In tube (QFT-IT) assays was evaluated for detection of M. tuberculosis (Mtb) infection in patients with suspected extra-pulmonary or smear-negative pulmonary tuberculosis (TB) in a low prevalence country. Twenty-one out of 35 patients were affected by active TB. Mtb culture isolation was achieved in 76% of cases. Tuberculin skin testing (TST), TS-TB, and QFT-IT yielded a positive result in 67%, 95% and 81% of cases, respectively. Agreement of interferon-gamma release assays and TST was 70% (kappa=0.18 for TS-TB; kappa=0.46 for QFT-IT). Increased sensitivity of blood assays (>80%) improved diagnostic evaluation of difficult TB cases.

引用

页码：43 / 47

页数：5

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