Low rate of HIV-1 codon 215 revertants in anti retroviral-experienced patients

被引：4

作者：

Gallego, O ^{[1
]}

de Mendoza, C ^{[1
]}

Corral, A ^{[1
]}

Soriano, V ^{[1
]}

机构：

[1] Inst Salud Carlos III, Hosp Carlos III, Infect Dis Serv, Madrid, Spain

来源：

AIDS | 2003年 / 17卷 / 06期

关键词：

D O I：

10.1097/00002030-200304110-00020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Novel codon T215C/D/N/S mutations have been described in antiretroviral-naive patients infected with zidovudine-resistant HIV-1-carrying 215F/Y. Viruses with codon 215-revertant genotypes are sensitive to zidovudine and stavudine, but rapidly develop resistance under exposure to these drugs. In pre-treated HIV-infected patients who discontinue zidovudine or stavudine there is no evidence of reversion to these unusual genotypes, because of an overgrowth of preexisting wild-type viruses. Therefore, these novel codon 215 mutations almost always reflect a past primary infection with zidovudine-resistant viruses.

引用

页码：919 / 921

页数：3

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