The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants

被引:861
作者
Heese, Antje
Hann, Dagmar R.
Gimenez-Ibanez, Selena
Jones, Alexandra M. E.
He, Kai
Li, Jia
Schroeder, Julian I.
Peck, Scott C.
Rathjen, John P.
机构
[1] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA
[2] Sainsbury Lab, Norwich NR4 7UH, Norfolk, England
[3] Univ Oklahoma, Dept Bot & Microbiol, Norman, OK 73019 USA
[4] Univ Calif San Diego, Div Biol Sci Cell & Dev Biol, La Jolla, CA 92093 USA
关键词
flg22; Arabidopsis; nicotiana; flagellin; brassinosteroid;
D O I
10.1073/pnas.0705306104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), plant cell surface receptors sense potential microbial pathogens by recognizing elicitors called PAMPs. Although diverse PAMPs trigger PTI through distinct receptors, the resulting intracellular responses overlap extensively. Despite this, a common component(s) linking signal perception with transduction remains unknown. In this study, we identify SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK)3/brassinosteroid-associated kinase (BAK)1, a receptor-like kinase previously implicated in hormone signaling, as a component of plant PTI. In Arabidopsis thaliana, AtSERK3/BAK1 rapidly enters an elicitor-dependent complex with FLAGELLIN SENSING 2 (FLS2), the receptor for the bacterial PAMP flagellin and its peptide derivative flg22. In the absence of AtSERK31BAK1, early fig22-dependent responses are greatly reduced in both A. thaliana and Nicotiana benthamiana. Furthermore, N. benthamiana Serk3/Bak1 is required for full responses to unrelated PAMPs and, importantly, for restriction of bacterial and oomycete infections. Thus, SERK3/BAK1 appears to integrate diverse perception events into downstream PAMP responses, leading to immunity against a range of invading microbes.
引用
收藏
页码:12217 / 12222
页数:6
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