Complex genetics of Wegener granulomatosis

被引：32

作者：

Jagiello, P

Gross, WL

Epplen, JT

机构：

[1] Ruhr Univ Bochum, Dept Human Genet, D-44801 Bochum, Germany

[2] Med Univ Lubeck, D-23538 Lubeck, Germany

来源：

AUTOIMMUNITY REVIEWS | 2005年 / 4卷 / 01期

关键词：

Wegener granulomatosis; multifactorial disease; predisposing genetic factor;

D O I：

10.1016/j.autrev.2004.06.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wegener granulomatosis (WG) belongs to a heterogeneous group of systemic anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitides (AASV). WG is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis and vasculitis. As a multifactorial model disease, WG is hallmarked by the presence of specific ANCA-subtypes directed against a defined antigen, WG is more predominant among Caucasians and the genetic predisposition appears quite complex. Here, we provide a brief overview concerning genetic factors in the pathogenesis of WG and discuss intricacies of molecular genetic approaches. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：42 / 47

页数：6

共 39 条

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