Angiotensin II signal transduction - Stimulation of multiple mitogen-activated protein kinase pathways

被引：46

作者：

Schmitz, U

Berk, BC

机构：

[1] Department of Medicine, Cardiology Division, University of Washington, Seattle

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1997年 / 8卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(97)00101-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin II (AngII)* is the main effector of the renin-angiotensin system and influences cell growth, migration, differentiation, and apoptosis. The mitogen-activated protein (MAP) kinase family of serine-threonine kinases integrates diverse extracellular stimuli and is involved in the regulation of cell growth and apoptosis. AngII regulates activity! of the MAP kinase family members extracellular regulated kinases (ERK1/2) and C-Jun N-terminal kinase (JNK). This review discusses the signal transduction pathways leading to ERK1/2 and JNK activation by AngII. (C) 1997, Elsevier Science Inc.

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收藏

页码：261 / 266

页数：6

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