Synthesis of 5′-deoxy-5′-[18F]fluoro-adenosine by radiofluorination of 5′-deoxy-5′-haloadenosine derivatives

被引：13

作者：

Lehel, S

Horváth, G

Boros, I

Mikecz, P

Márián, T

Trón, L

机构：

[1] Univ Debrecen, Sch Med, Positron Emiss Tomog Ctr, H-4012 Debrecen, Hungary

[2] Hungarian Acad Sci, PET Study Grp, H-1051 Budapest, Hungary

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2000年 / 245卷 / 02期

关键词：

D O I：

10.1023/A:1006791211919

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

5'-Deoxy-5`-[F-18]fluoro-adenosine was synthesised by nucleophilic radiofluorination reactions of 5'-deoxy-5'-haloadenosines. The homogeneous isotope exchange in 5'-deoxy-5'-fluoro-adenosine was also investigated. The conversion of these reactions was found to be rather low and depends on the strength of the halogen-carbon bond: 0.248% for chloride-, 0.488% for bromide- and 1.070% for iodide-derivative; there was no reaction observed in the case of fluoro-compound.

引用

页码：399 / 401

页数：3

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