Modulation of P-glycoprotein activity by acridones and coumarins from Citrus sinensis

被引：21

作者：

Bayet, C.

Fazio, C.

Darbour, N.

Berger, O.

Raad, I.

Chaboud, A.

Dumontet, C.

Guilet, D.

机构：

[1] Univ Lyon 1, Lab Pharmacognosie, Fac Pharm, F-69373 Lyon 8, France

[2] Univ Lyon 1, Lab Cytol Analyt, INSERM, U590,Fac Med Lyon, F-69880 Lyon, France

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 04期

关键词：

Citrus sinensis; acridones; coumarins; P-glycoprotein inhibitors;

D O I：

10.1002/ptr.2081

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2-methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2-methoxycitpressine I and acrimarine E inhibited P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells over-expressing P-glycoprotein. Copyright (c) 2007 John Wiley & Sons, Ltd.

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收藏

页码：386 / 390

页数：5

相关论文

共 28 条

[1]

CLAUSARIN NOVEL COUMARIN FROM CLAUSENA-PENTAPHYLLA-ROXB DC [J].

ANWER, F ;

SHOEB, A ;

KAPIL, RS ;

POPLI, SP .

EXPERIENTIA, 1977, 33 (04) :412-413

[2]

The combined effects of IL-3 and PSC 833 on daunorubicin- and mitoxantrone cytotoxicity in two growth factor-dependent leukemic cell lines [J].

Asschert, J ;

deVries, E ;

vanderKolk, D ;

Muller, M ;

Vellenga, E .

LEUKEMIA, 1997, 11 (05) :680-686

[3]

Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin [J].

Barthomeuf, C ;

Grassi, J ;

Demeule, M ;

Fournier, C ;

Boivin, D ;

Béliveau, R .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2005, 56 (02) :173-181

[4]

BOWEN H, 1986, PHYTOCHEMISTRY, V25, P429

[5]

CHANG PTO, 1976, LLOYDIA, V39, P134

[6]

C-isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance [J].

Comte, G ;

Daskiewicz, JB ;

Bayet, C ;

Conseil, G ;

Viornery-Vanier, A ;

Dumontet, C ;

Di Pietro, A ;

Barron, D .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (05) :763-768

[7]

DI PA, 2002, CELL MOL LIFE SCI, V59, P307

[8]

SPECTROMETRIC ELUCIDATION OF ACRIMARINES, THE 1ST NATURALLY-OCCURRING ACRIDONE COUMARIN DIMERS [J].

FURUKAWA, H ;

ITO, C ;

MIZUNO, T ;

JUICHI, M ;

INOUE, M ;

KAJIURA, I ;

OMURA, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (06) :1593-1599

[9]

Goldstein L J, 1995, Curr Probl Cancer, V19, P65

[10]

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux [J].

Honda, Y ;

Ushigome, F ;

Koyabu, N ;

Morimoto, S ;

Shoyama, Y ;

Uchiumi, T ;

Kuwano, M ;

Ohtani, H ;

Sawada, Y .

BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (07) :856-864