No carrier added preparations of '3+1' mixed-ligand 99mTc complexes

被引：25

作者：

Seifert, S ^{[1
]}

Pietzsch, HJ ^{[1
]}

Scheunemann, M ^{[1
]}

Spies, H ^{[1
]}

Syhre, R ^{[1
]}

Johannsen, B ^{[1
]}

机构：

[1] Res Ctr Rossendorf Inc, Inst Bioorgan & Radiopharmaceut Chem, D-01314 Dresden, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 1998年 / 49卷 / 1-2期

关键词：

D O I：

10.1016/S0969-8043(97)00221-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The no carrier added (n.c.a.) preparation of potentially receptor-binding '3 + 1' mixed-ligand technetium complexes has not so far been successfully accomplished. This article deals with our results in the preparation of n.c.a. Tc complexes with tridentate S-S-S or S-NS ligands and a series of bulky monothiolato ligands. It was found that Tc(V) gluconate or Tc(V) ethylene glycolate are suitable precursors for the complex formation. In a two-step procedure consisting of a reaction of the monothiolato ligand with the precursor and subsequent addition of the tridentate ligand, the desired '3 + 1' mixed-ligand complexes are formed with yields of up to 90%. Low ligand concentrations and pH 9-10 promote the formation of the technetium compounds. A comparison of their analytical properties (TLC, HPLC) and biodistribution data of carrier added and no carrier added technetium complexes show the identity of the investigated compounds. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：5 / 11

页数：7

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