Inhibition of human N-type voltage-gated Ca2+ channels by the neuroprotective agent BW619C89

被引：14

作者：

McNaughton, NCL

Leach, MJ

Hainsworth, AH

Randall, AD

机构：

[1] MRC, Mol Biol Lab, Div Neurobiol, Cambridge CB2 2QH, England

[2] Univ Greenwich, Sch Life Sci, London SE18 6PF, England

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 11-12期

基金：

英国医学研究理事会;

关键词：

calcium channel; pharmacology; neuroprotection; ischemia;

D O I：

10.1016/S0028-3908(97)00187-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human N-type Ca2+ channels were rapidly and reversibly inhibited by 5-100 mu M BW619C89 (IC50 = 16.4 mu M at V-test = + 10 mV and V-hold = -90 mV). In the presence of 20 mu M BW619C89, activation kinetics were significantly faster. The degree of inhibition observed was affected by both test and holding potential, indicating state-dependent interactions with the N-type Ca2+ channel. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1795 / 1798

页数：4

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