The anaphase-promoting complex:: a key factor in the regulation of cell cycle

被引：231

作者：

Castro, A ^{[1
]}

Bernis, C ^{[1
]}

Vigneron, S ^{[1
]}

Labbé, JC ^{[1
]}

Lorca, T ^{[1
]}

机构：

[1] Ctr Rech Biochim Macromol, CNRS, FRE 2593, F-34293 Montpellier 5, France

来源：

ONCOGENE | 2005年 / 24卷 / 03期

关键词：

APC; cdc20; cdh1; proteolysis; mitosis;

D O I：

10.1038/sj.onc.1207973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation by the 26S proteasome. Two different ubiquitin ligases play an important role in the cell cycle: the SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC). In this review, we describe the present knowledge about the APC. We pay particular attention to the latest results concerning APC structure, APC regulation and substrate recognition, and we discuss the implication of these findings in the understanding the APC function.

引用

页码：314 / 325

页数：12

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