Engulfment: Ingestion and migration with Rac, Rho and TRIO

被引：25

作者：

Henson, PM ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Denver, CO 80206 USA

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.cub.2004.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptotic cells are removed from tissues by uptake mechanisms that depend on the GTPase Rac (CED-10 in C. elegans), which is activated by DOCK180/CED-5 in a trimolecular complex with ELMO/CED-12 and CrkII/CED-2. A study now identifies upstream components of this pathway in both worms and mammalian cells involving yet another GTPase, RhoG/MIG-2, and its activator TRIO/UNC-73.

引用

页码：R29 / R30

页数：2

共 9 条

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