The effects of single-dose tramadol on post-operative pain and morphine requirements after coronary artery bypass surgery

被引:18
作者
But, A. K. [1 ]
Erdil, F. [1 ]
Yucel, A. [1 ]
Gedik, E. [1 ]
Durmus, M. [1 ]
Ersoy, M. O. [1 ]
机构
[1] Inonu Univ, Sch Med, Dept Anaesthesiol, Malatya, Turkey
关键词
coronary artery bypass grafting; morphine; post-operative pain; tramadol;
D O I
10.1111/j.1399-6576.2007.01275.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Aim: To investigate the effects of a single dose of tramadol administered prior to extubation on post-operative pain and morphine consumption after coronary artery bypass surgery. Methods: Patients were randomized post-operatively into two groups (group T, n=30; group P, n=30). The technique of anaesthesia was standardized for all patients. The patients in group T received intravenous tramadol, 1 mg/kg, and the patients in group P received 2 ml of saline 0.9%, both approximately 1 h before extubation. After extubation, all patients were allowed to use the morphine patient-controlled analgesia (PCA) device for 24 h post-operatively. Post-operative data were recorded in the cardiac intensive care unit at 30 min, 1 h, 2 h, 4 h, 12 h and 24 h after extubation by the same anaesthesiologist, who had no knowledge of the groups, and the side-effects were also evaluated. Results: In group P, the visual analogue scale (VAS) scores were found to be higher 30 min (P < 0.01), 1 h (P < 0.01), 2 h (P < 0.01) and 4 h (P < 0.05) after extubation. The patient comfort scores were higher in group T 30 min (P < 0.01), 1 h (P < 0.05), 2 h (P < 0.01) and 4 h (P < 0.01) after extubation. The total morphine consumption was higher in group P at all evaluation times (P < 0.01), and the numbers of PCA demands and boluses were also higher in group P (P < 0.01). Conclusions: The study demonstrated that a single dose of tramadol administered prior to extubation following coronary artery bypass surgery is associated with a decrease of up to 25% in morphine consumption, a decrease in the VAS scores and an improvement in patient comfort within the first 4 h post-operatively.
引用
收藏
页码:601 / 606
页数:6
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