RNA traffic control of chromatin complexes

被引：138

作者：

Koziol, Magdalena J. ^{[1
,2
]}

Rinn, John L. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, BIDMC Dept Pathol, Boston, MA 02215 USA

[2] Broad Inst, Cambridge, MA 02142 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期

关键词：

INACTIVE X-CHROMOSOME; NONCODING RNAS; HISTONE H3; POLYCOMB GENE; HOX GENES; MOUSE; HETEROCHROMATIN; METHYLATION; EXPRESSION; ANTISENSE;

D O I：

10.1016/j.gde.2010.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is widely accepted that the genome is regulated by histone modifications that induce epigenetic changes on the genome. However, it is still not understood how ubiquitously expressed chromatin modifying complexes are 'guided' to specific genomic sites to induce intricate patterns of epigenetic modifications. Previously believed to represent 'genome junk', it is now becoming increasingly clear that large non-coding RNAs associate with chromatin modifying complexes. Here we explore an intriguing hypothesis that large non-coding RNA molecules might represent a molecular trafficking system that modulates chromatin modifying complexes to establish specific epigenetic landscapes.

引用

页码：142 / 148

页数：7

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