Metals ions and neurodegeneration

被引：167

作者：

Molina-Holgado, Francisco

Hider, Robert C. ^{[1
]}

Gaeta, Alessandra

Williams, Robert

Francis, Paul

机构：

[1] Kings Coll London, Div Pharmaceut Sci, London WC2R 2LS, England

[2] Kings Coll London, Wolfson Ctr Age Related Dis, London WC2R 2LS, England

来源：

BIOMETALS | 2007年 / 20卷 / 3-4期

关键词：

neurodegeneration; protein aggregation; oxidative stress; A beta-amyloid; alpha-synuclein; chelation therapy; iron;

D O I：

10.1007/s10534-006-9033-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.

引用

页码：639 / 654

页数：16

共 126 条

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