CCR5 is characteristic of Th1 lymphocytes

被引：749

作者：

Loetscher, P ^{[2
]}

Uguccioni, M

Bordoli, L

Baggiolini, M

Moser, B

机构：

[1] Univ Hosp Bern, Div Rheumatol, CH-3010 Bern, Switzerland

[2] Univ Bern, Theodor Kocher Inst, CH-3000 Bern 9, Switzerland

[3] Univ Hosp Geneva, Div Immunol & Allergy, CH-1211 Geneva, Switzerland

来源：

NATURE | 1998年 / 391卷 / 6665期

关键词：

D O I：

10.1038/34814

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4.

引用

页码：344 / 345

页数：2

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